专利内容由知识产权出版社提供
专利名称：Uses of DC-SIGN and DC-SIGNR for inhibiting
hepatitis C virus infection
发明人：William C. Olson,Paul J. Maddon申请号：US11397236申请日：20060404公开号：US07446177B2公开日：20081104
摘要：This invention provides a method of inhibiting HCV infection of a cell susceptibleto HCV infection which comprises contacting the cell with an amount of a compoundeffective to inhibit binding of an HCV envelope glycoprotein to a DC-SIGN proteinpresent on the surface of the cell, so as to thereby inhibit HCV infection of the cellsusceptible to HCV infection. This invention provides a method of inhibiting HCV infectionof a cell susceptible to HCV infection which comprises contacting the cell with an amountof a compound effective to inhibit binding of an HCV envelope glycoprotein to a DC-SIGNR protein present on the surface of the cell, so as to thereby inhibit HCV infection ofthe cell susceptible to HCV infection. Compounds of the present invention inhibit HCVinfection of cells susceptible to HCV infection. The compounds of the present inventionpreferably have specificity for preventing or inhibiting infection by HCV and do not inhibitinfection by other viruses, such as HIV, that may utilize DC-SIGN or DC-SIGNR for
infection. Moreover the compounds of the present invention preferably do not interfereor inhibit members of the immunoglobulin superfamily, in particular, the compounds donot interfere with ICAM-2 or ICAM-3 or with ICAM-2-ilke, or ICAM-3-like molecules.
申请人：William C. Olson,Paul J. Maddon
地址：Ossining NY US,Scarsdale NY US
国籍：US,US
代理机构：Cooper & Dunham LLP
代理人：John P. White
更多信息请下载全文后查看